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However, derepression away from ThPOK transcription in DP thymocytes off ThPOKCD4.Sil mice mirrors expression away from endogenous Cd4 inside DP thymocytes regarding wt mice. Particularly, the fresh new SilThPOK suppress this new transcription out-of Cd4 when you look at the DP thymocytes away from CD4ThPOK.Sil rats much like the suppression out of endogenous ThPOK within the DP thymocytes out-of wt mice. FACS analysis off TCR?, CD69, CD4, and CD8 term regarding (b) overall thymocytes, gated thymocytes and you will (c) peripheral T-mobile subsets away from wt rats or mutant outlines, as the indicated. Statistical benefit is computed per indicated mutant range relative to wt rats. FACS study regarding TCR?, CD69, CD4, and you can CD8 term regarding total thymocytes, gated thymocytes (c), and you may peripheral T-telephone subsets (d) out of wt rats otherwise mutant contours, just like the conveyed.

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